Chargaff's rule of DNA | Biology Guide

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                                      Chargaff's Rule 





Erwin Chargaff's proposed two rules which are known as chargaff rules. This role plays a key role in double helix structure discovery. Here the rules are : -

Rule 1 -  In DNA structure the total number of purines is equal to a total number of pyrimidine .,i.e., the number of guanine units is equal to the number of cytosine unit and the number of adenine units is equal to thymine units.

Rule 2 -   In every species there is a unique composition of  DNA  is present in its body.


Hence ,  in double stranded structure of DNA
                                      A = T =  1
                                      G = C =  1
                Also, the percentage of C + G does not essentially equal to the percentage of A+ T     

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