Chargaff's Rule
Erwin Chargaff's proposed two rules which are known as chargaff rules. This role plays a key role in
double helix structure discovery. Here the rules are : -
Rule 1 - In DNA structure the total number of purines is equal to a total number of pyrimidine .,i.e., the number of guanine units is equal to the number of cytosine unit and the number of adenine units is equal to thymine units.
Rule 2 - In every species there is a unique composition of DNA is present in its body.
Hence , in double stranded structure of DNA
A = T = 1
G = C = 1
Also, the percentage of C + G does not essentially equal to the percentage of A+ T
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